Moclobemide versus placebo in the treatment of depression: a multicentre study in Belgium.

Botte L, Gilles C, Evrard JL, Mesters P, Wolfrum C, Berger M, Hellstern 

Centre Hospitalier de Tivoli
 La Louviere, Belgium.
Acta Psychiatr Scand Suppl 1990;360:42 

ABSTRACT

Moclobemide was compared with placebo for antidepressant activity, tolerance and safety in 2 parallel groups of 23 and 24 depressed patients. At the end of treatment (4 weeks or longer), 9 patients on moclobemide (41%) showed an improvement greater than or equal to 50% on the Hamilton Rating Scale for Depression, compared with only 4 (17%) of those on placebo. The overall assessment of efficacy was significantly better for moclobemide (good or very good results in 50% of patients) than for placebo (80% poor results). Moclobemide was well or very well tolerated by 85% of patients and placebo by 100%. Moclobemide was thus shown to be clearly more effective than placebo and only slightly less well tolerated.

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