Pyritinol has been used clinically in a wide range of disorders including cerebral circulatory disorders, alcoholism, dyslexia, behavioral disorders in children, and stroke.
1. Pyritinol may be useful in various forms of dementia, head injury, stroke aftermath, coma, and cerebral circulatory disorders.
2. Pyritinol may be useful as an anti-brain aging, cognitive enhancing agent.
3. Pyritinol may be useful as an aid to improved memory, concentration, alertness and information processing in both young and old.
4. Pyritinol may be useful in Attention Deficit Disorder (ADD).
Pyritinol has been used following head injury and cerebral trauma. Pyritinol has reduced the normal high death rate in such cases and has rapidly returned coma patients to more or less normal waking consciousness, even when the brain injuries were so severe the patient ultimately died.
Pyritinol has the ability to enhance glucose transport through the blood-brain
barrier. Although the brain is usually less than 2% of total bodyweight, the
brain uses about 20% of the body's total energy production. Under normal,
non-fasting conditions, the brain can only 'burn' glucose (sugar) for fuel.
Unlike virtually all other body cells, nerve cells cannot use fat as an energy
fuel. Brain cells also cannot store any significant amount of glucose - they are
completely dependent upon a continuous delivery of glucose from the blood,
through the blood-brain barrier. Thus, brain glucose uptake is a major
rate-limiting factor for crucial brain energy production. Pyritinol has the
ability to increase glucose transport through the blood-brain barrier.
K. Fischhof et al (1992) "Therapeutic Efficacy of Pyritinol in Patients with Senile Dementia of the Alzheimer Type
(SDAT) and Multi-Infarct Dementia" Neuropsychobiol 26, 65-70.
K.Kitamura (1981) "Therapeutic Effect of Pyritinol on Sequelae of Head Injuries" J Int Med Res 9, 215-21.
G. Dalle Ore et al (1980) "The Influence of the Administration of Pyritinol on the Clinical Course of Traumatic Coma", J Neuroserg Sci 24, 1-8.
E.M. Lemmel (1993)
of Pyritinol and Auranofin in the Treatment of Rheumatoid Arthritis"
Br J Rheumatol 32, 375-82.
I. Hindmarch et al
Effects of Pyritinol in Normal Volunteers" Neuropsychobiol
A. Pavlik & J.
Pilar (1989) "Protection
of Cell Proteins Against Free-Radical Attack by Nootropic Drugs:
Scavenger Effects of Pyritinol Confirmed by Electron Spin Resonance
Spectroscopy" Nueropharmacol 28, 557-61.
S. Hoyer et al (1977) "Effect of Pyritinol-HCL on Blood Flow and Oxidative Metabolism of the Brain in Patients with Dementia" Arzneim Forsch/Drug Res 27, 671-74.
R. Branconnier (1983) "The Efficacy of the Cerebral Metabolic Enhancers in the Treatment of Senile Dementia" Psychopharmacol Bull 1983 Spring;19(2):212-9.
G. Logue et al (1974) "The Effects of Pyritinol on the Behavior and Intellectual Functioning of Learning-Disabled Children" S.Afr Med J 48, 2245-46.
D. Lane O'Kelly (1975) "Pyritinol in the Treatment of Chronic Alcoholics" J Int Med Res 3, 323-27.
A. Cooper & R. Magnus (1980) "A Placebo-Controlled Study of Pyritinol in Dementia" Pharmatherapeutica 2, 317-22.