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Alpha Lipoic Acid
 Alpha Lipoic Acid is a sulfurous fatty acid that would
have been classified as a Vitamin except for the fact that it can be synthesized
within the human body.
Lipoic Acid helps to prevent Age-Related Macular Degeneration (ARMD) (due to the
Antioxidant properties of Lipoic Acid; Lipoic Acid can penetrate eye tissue and
protect both the Lens and the Retina from degeneration).
Lipoic Acid protects the lens and retina of the eye from degeneration.
Lipoic Acid alleviates Glaucoma (after 1 month of treatment with 150 mg of
Lipoic Acid per day 47% of persons with Glaucoma exhibited improvement in visual
acuity, visual field color discrimination and increased lacrimal tear fluid)
Lipoic Acid reduces the incidence of cataracts in persons with Diabetes.
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Lipoic Acid normalizes blood sugar levels.
Lipoic Acid (300 - 600 mg per day) reduces Insulin Resistance (i.e. it increases
Insulin sensitivity).
Lipoic Acid prevents and alleviates many of the detrimental side effects that
occur as a result of Diabetes Mellitus (both Type 1 and Type 2).
Lipoic Acid prevents the (diabetic) Neuropathy that is a common side effect of
Diabetes Mellitus [Lipoic Acid improves nerve blood flow, reduces oxidative
stress and improves distal nerve conduction in experimental diabetic
neuropathy].
Lipoic Acid is a potent scavenger of Hydroxyl Free Radicals.
Lipoic Acid inhibits the cross-linking of the body’s Proteins.
Lipoic Acid is used therapeutically to treat Liver ailments and it protects the
Liver from the toxic effects of many Pharmaceutical Drugs.
Lipoic Acid is an effective therapy in the treatment of food poisoning by toxic
mushrooms.
Lipoic Acid helps to recycle Vitiams C and E.
References
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Baur, A., et al. Alpha-lipoic acid is an effective
inhibitor or human immuno-deficiency virus (HIV-1) replication. Klin Wochenschr
. 69:722-724, 1991.
· Fuchs, J., et al. Studies on lipoate effects on blood redox state in human
immunodeficiency virus infected patients. Arzneim Forsch. 43:1359-1362, 1993.
· Ou, P., et al. Thioctic (lipoic) acid: A therapeutic metal-chelating
antioxidant? Biochem Pharmacol. 50:123-126, 1995.
· Packer, L. Antioxidant properties of lipoic acid and its therapeutic effects
in prevention of diabetes complications and cataracts. Annals NY Acad Sci.
738:257-264, 1994.
· Packer, L., et al. Alpha-lipoic acid as a biological antioxidant. Free Rad
Biol Med. 19:227-250, 1995.
· Shih, J. C. H. Atherosclerosis in Japanese quail and the effect of lipoic
acid. Fed Proc. 42:2494-2497, 1983.
· Suzuki, Y. J., et al. Lipoate prevents glucose-induced protein modifications.
Free Rad Res Comms. 17:211-217, 1992.
· Kawataba, T., et al. Alpha-lipoate can protect against glycation of serum
albumin, but not low density lipoprotein. Biochem Biophys Res Comm. 203:99-104,
1994.
· Xu, D. P., et al. Alpha-lipoic acid dependent regeneration of ascorbic acid
from dehydroascorbic acid in rat liver mitochondria. J Bioenerg Biomembr.
28(1):77-85, 1996.
· Faust, A., et al. Effect of lipoic acid on cyclophosphamide-induced diabetes
and insulitis in non-obese diabetic mice. Int J Immunopharmacol. 16(1):61-66,
1994.
· Jacob, S., et al. Enhancement of glucose disposal in patients with type 2
diabetes by alpha-lipoic acid. Arzneimittel-Forschung. 45:872-874, 1995.
· Jacob, S., et al. The antioxidant -lipoic acid enhances insulin-stimulated
glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes.
45:1024-1029, 1996.
· Wagh, S. S., et al. Mode of action of lipoic acid in diabetes. Journal of
Bioscience. 11:59-74, 1987.
· Ziegler, D., et al. Effects of treatment with the antioxidant alpha-lipoic
acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized
controlled multicenter trial (DEKAN Study). Diabetes Care. 20(3):369-373, 1997.
· Altenkirch, H., et al. Effects of lipoic acid in hexacarbon-induced
neuropathy. Neurotoxicol Teratol. 12:19-22, 1990.
· Nagamatsu, M., et al. Lipoic acid improves nerve blood flow, reduces
oxidative stress, and improves distal nerve conduction in experimental diabetic
neuropathy. Diabetes Care. 18:1160-1167, 1995.
· Filina, A. A., et al. Lipoic acid as a means of metabolic therapy of
open-angle glaucoma. Vestnik Oftalmologii, 111:68, 1995.
· Haugaard, N., et al. Stimulation of glucose utilization by thioctic acid.
Biophys Acta. 222:583-586, 1970.
· Matsugo, S., et al. Elucidation of antioxidant activity of alpha-lipoic acid
toward hydroxyl radical. Biochem Biophys Res Comm. 208:161-167, 1995.
· Wolz, P., et al. Neuropharmacology. 35:369-375, 1996.
· Ou, P., et al. Thioctic (lipoic) acid: A therapeutic metal-chelating
antioxidant? Biochem and Pharmacology. 1(123):123-126, 1995.
· Xu, D. P., et al. Alpha-lipoic acid dependent regeneration of ascorbic acid
from dehydroascorbic acid in rat liver mitochondria. J Bioenerg Biomembr.
28(1):77-85, 1996.
· Podda, M., et al. Alpha-lipoic acid supplementation prevents symptoms of
vitamin E deficiency. Biochem Biophys Res Comm 204:98-104, 1994.
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